恰加斯心脏疾病的骨髓源性细胞疗法:临床前和临床结果回顾
Review Article

恰加斯心脏疾病的骨髓源性细胞疗法:临床前和临床结果回顾

Antonio Carlos Campos de Carvalho1,2, Adriana Bastos Carvalho2, Debora Bastos Mello2, Regina Coeli dos Santos Goldenberg2

1Instituto Nacional de Cardiologia, Rua das Laranjeiras 374, Rio de Janeiro, RJ-22240-006, Brazil; 2Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Rio de Janeiro, RJ-21941-902, Brazil

Corresponding to:
Antonio Carlos Campos de Carvalho. Rua das Laranjeiras 374, 5º andar. Rio de Janeiro-RJ, 22240-006-Brazil.
Email: acarlos@biof.ufrj.br.

摘要: 恰加斯病是由原生动物寄生虫克氏锥虫引起的,通过吸血虫感染人类。它在拉丁美洲盛行,并随着感染者的迁移传播至发达国家。恰加斯病在其慢性阶段可以导致严重的心肌病,目前尚无治疗方法。终末期患者需要心脏移植,因此形成了对新治疗方法的需求。细胞治疗可作为各种心脏疾病的替代治疗。本文回顾了推动动物模型和临床试验中认定细胞干细胞疗法作为慢性恰加斯心肌病治疗的试验依据,并讨论了试验结果从小鼠到人类的转化失败的原因。

Key words: 骨髓;心肌病;恰加斯病;细胞治疗

Submitted Jul 20, 2012. Accepted for publication Aug 22, 2012.
DOI: 10.3978/j.issn.2223-3652.2012.08.03

Cite this article as: de Carvalho AC, Carvalho AB, Mello DB, Goldenberg RC. Bone marrow-derived cell therapy in chagasic cardiac disease: a review of pre-clinical and clinical results. Cardiovasc Diagn Ther 2012;2(3):213-219. DOI: 10.3978/ j.issn.2223-3652.2012.08.03