血管紧张素Ⅱ2型受体对心血管系统的影响
Cite this article as: Li Y, Li XH, Yuan H. Angiotensin II type-2 receptorspecific effects on the cardiovascular system. Cardiovasc Diagn Ther 2012;2:56-62. DOI: 10.3978/j.issn.2223-3652.2012.02.02
Review Article

血管紧张素Ⅱ2型受体对心血管系统的影响

Ying Li1, Xiao-hui Li2, Hong Yuan1

1Center of Clinical Pharmacology, third Xiangya hospital, Central South University, Changsha 410013, China; 2Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China

Conflict of interest: Dominique de Kleijn, Frans Moll and Gerard Pasterkamp are cofounders of a biomarker company CAVADIS.

Corresponding to:
Hong Yuan. Center of Clinical Pharmacology, third Xiangya hospital, Central South University, Changsha, China.
Tel/Fax: +86-731-88638888. Email: yuanhong01@vip.sina.com.

摘要:

肾素-血管紧张素系统(RAS)与心血管内稳态有着错综复杂的关系。众所周知,血管紧张素Ⅱ,也即RAS的重要效应因子,通过激活血管紧张素Ⅱ1型受体(AT1R),来作用于心血管疾病及其病理学。然而,血管紧张素Ⅱ2型受体(AT2R)调节则不太好理解。近期研究描述了AT2R在正常情况及病理条件下对心血管功能的影响,阐述了AT2R在调节血压、心脏肥大、心脏纤维化、心肌梗死及血管内稳态方面的重要作用。

Keywords

Rennin-angiotensin system; AT2 receptor; cardiovascular disease

Cardiovasc Diagn Ther 2012;2:56-62. DOI: 10.3978/j.issn.2223-3652.2012.02.02