Article Abstract

Cardiovascular Diagnosis and Therapy (CDT) Editorial: the Minimalist Immediate Mechanical Intervention study

Authors: Muhammad Aetesam-ur-Rahman, Colin Berry


Primary percutaneous coronary intervention (PCI) has become the standard of care in patients presenting with ST Elevation Myocardial Infarction (STEMI) (1). However, since stent implantation may cause intra-procedural thrombotic complications (IPTEs), including distal embolization of thrombus leading to microvascular obstruction (MVO) and no-reflow (2,3) some clinicians have questioned whether immediate stent implantation is mandated in all patients, or instead, whether stent implantation could be deferred for a limited period to enable the beneficial effects of restored blood flow and medical therapy. With this in mind, a number of clinical investigations of deferred stenting (DS) strategies have been assessed (4-16). This was the focus of the Minimalist Immediate Mechanical Intervention (MIMI) trial (14).