Echocardiographic assessment of right ventricular systolic function
Review Article

Echocardiographic assessment of right ventricular systolic function

Victor Chien-Chia Wu1,2, Masaaki Takeuchi1

1Department of Laboratory and Transfusion Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan; 2Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan

Contributions: (I) Concept and design: All authors; (II) Administrative support: M Takeuchi; (III) Provision of study materials or patients: M Takeuchi; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Masaaki Takeuchi, MD, PhD, FASE, FESC, FJCC. Department of Laboratory and Transfusion Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Email:

Abstract: Assessment of right chamber function has become increasingly popular and important in recent decades, complementing the evaluation of left chamber functional parameters. The late adoption and integration of right ventricular (RV) function into a complete evaluation of cardiac function could be due in part to the difficulty in visualization of the whole right ventricle, inconsistency in the analysis of RV parameters, and poor understanding of the impact of RV function on prognosis. From M-mode to 2-dimensional (2D) measurements of RV size and function, there have been arrays of parameters that provide important information of the right ventricle. However, there are limitations of using 2D echocardiography to quantify RV volume and ejection fraction (EF), and currently accurate measurements of RV volumes and EF can be obtained using cardiac magnetic resonance (CMR) imaging. Using 3-dimensional echocardiography (3DE), the measurements of RV volumes and EF have become feasible and reproducible. Importantly, 3D measurements have been validated against CMR with higher correlation compared to 2D measurements. With the establishment of reference values, 3D echocardiography determined RV volumes and EF have the potential for better understanding of RV function and exploration of its significance for outcome research in various clinical scenarios.

Keywords: Right ventricular function (RV function); 2-dimensional echocardiography (2DE); 3D echocardiography (3DE)

Submitted Jan 17, 2017. Accepted for publication Jun 02, 2017.

doi: 10.21037/cdt.2017.06.05


Two-dimensional echocardiography (2DE) is an indispensable and integral part of clinical evaluation of patients with various cardiac diseases. However, most of the parameters derived from cardiac ultrasound examination mainly focus on the left chamber function, and less attention has been paid to the study and interpretation of right chamber function, namely the right ventricular (RV) systolic function. Early beliefs considered the importance of right ventricle is subservient to the left ventricle (1). This is because the knowledge of RV function lagged behind the left ventricular (LV) function and less is understood about the physiologic and prognostic roles of the right ventricle. Indeed, the inherent challenges in accurate assessment of irregular shaped RV cavity have hindered such progress. Strictly speaking, 2DE determined RV function parameters do not represent global function of the entire right ventricle, and it is almost impossible to precisely estimate RV volume and RV ejection fraction (RVEF) from few 2DE views. Nonetheless, right heart parameters are particularly important in patients whose diseases primarily affect the right ventricle, including congenital heart disease, pulmonary hypertension, valvular heart disease, ischemic heart disease, and chronic lung disease. RV function is also important in patients whose pathology is caused by the abnormality of the left heart chamber function. Recent advances in the study of RV function have made strides with establishment of reference values assessed by 3D echocardiography (3DE), from which cutoff values may provide predictive values for future events. In this review, we present a summary of RV systolic function parameters derived from 2DE and 3DE (Table 1) and their evidence and recommendations from current literature and guidelines on the acquisition, analysis, and application of these measurements.

Table 1
Table 1 Methods of echocardiographic evaluation of right ventricular function
Full table

Anatomy of right ventricle

The heart is located in the middle mediastinum, at the level of thoracic vertebrae T5–T8. The right ventricle is situated immediately posterior to the sternum and anteromedial to the left ventricle. The ratio of RV volume to LV volume is 0.91–1.27 with no gender differences (2), and the RV mass is approximately one-sixth of the LV mass (3). In contrast to the conical shape of the left ventricle, the shape of RV resembles a triangular crescentic shell attached to anterior and inferior left ventricle at interventricular septum, sharing the same border, and the right ventricle appears to wrap around part of the left ventricle. The right ventricle is divided into three major components, including the inflow tract, the trabeculated apex, and the infundibulum or RV outflow tract. Due to its arcuate nature, it has a short-axis cross-sectional falcate shape. There are numerous trabeculae within the RV cavity with three prominent muscular bands: the parietal band, the septomarginal band, and the moderator band. The parietal band and the infundibular septum form the crista supraventricularis, and the septomarginal band extends inferiorly and connects with the moderator band to which it attaches to the anterior papillary muscle. To assess RV dimension, volume, and function, American Society of Echocardiography Guidelines suggest evaluation through apical 4-chamber, modified 4-chamber, left parasternal long-axis (PLAX) and parasternal short-axis (PSAX), left parasternal RV inflow, and subcostal views for comprehensive assessment of right ventricle (4).

Physiology of right ventricle

Right heart receives systemic venous return and pumps blood into pulmonary circulation, whereas left heart receives pulmonary venous return and pumps blood into systemic circulation. In theory, the right heart pumps about the same amount of blood as the left heart in each cardiac cycle. The right heart and left heart are connected in series and an interruption at any point of circulation can affect both right and left heart. Since right ventricle is filled with deoxygenated blood, RV wall is thinner than LV wall, and the chamber is highly compliant and very sensitive to preload. RV systolic function is a combination of preload, afterload, and contractility just like LV systolic function. Frank-Starling mechanism operates in the right ventricle where an increase in preload stretches RV wall resulting in enhanced myocardial contractility in the same way as left ventricle does. The RV preload is affected by intravascular volume status, ventricular compliance, ventricular relaxation, heart rate, and filling pressure. Under normal condition, the right heart pumps oxygen-deprived blood with much lower pressure compared to the left heart, hence the right heart has lower impedance and higher distensibility. Isovolumic contraction time of the right ventricle is shorter than that of the left ventricle also due to RV pressure is able to rise faster to exceed the low pulmonary artery (PA) pressure (5). A study of RV pressure tracings show an early peaking and a rapidly declining pressure in contrast to the rounded contour of LV pressure tracing (6). The RV afterload is related to pulmonary vascular resistance (PVR) and PA pressure.

The understanding of complex relationship between RV contractility, preload, and afterload can be enhanced by the pressure-volume (P-V) loops. RV systolic pressure (RVSP) can be determined from peak tricuspid regurgitation (TR) velocity by the simplified Bernoulli equation in addition to right atrial (RA) pressure: RVSP = 4 (TR velocity)2 + RA pressure. PA systolic pressure is estimated also from TR velocity, and PA diastolic pressure is obtained by end-diastolic pulmonary regurgitation velocity. The normal mean PA pressure is less than 25 mmHg. In routine practice, RVSP is more commonly measured and normal resting value is defined as RVSP ≤35–36 mmHg (peak TR velocity ≤2.8–2.9 m/s, assuming an RA pressure 3–5 mmHg) (4). Care must be taken to evaluate patients with increased PA pressure as afterload can be related to increased PVR. PVR can be estimated by the ratio of peak TR velocity over RV outflow tract velocity-time integral with units in Wood (7). A normal PVR is <1.5 Wood units and a significant pulmonary hypertension is defined as >3 Wood units (4).

In pathologic states that primarily affects the right ventricle, both volume and pressure overload can cause RV hypertrophy and enlargement. In diseases that causes RV pressure overload, RV wall thickens and in extreme cases such as congenital heart disease with Eisenmenger syndrome or severe pulmonary hypertension, the shape of ventricles is reversed, and the left ventricle becomes D-shaped. The complex interaction and relationship between RV contractility, preload, and afterload is better comprehended by P-V loop. The slop of this RV P-V loop is referred to as ventricular elastance, and is a reliable index of RV contractility (8).

Importance of acquisition of the RV focused view

Although the right ventricle can be visualized on the standard apical 4-chamber view, acquisition of RV-focused apical 4-chamber view is vital for its full delineation of the RV free wall, especially for the measurements of RV free wall longitudinal strain (LS) (Figure 1). The transducer should be placed more laterally to the point where the usual apical 4-chamber view is acquired. The sector size should be reduced as much as possible to increase frame rate. The same technique should also be applied when acquiring 3DE full volume datasets.

Figure 1 A representative case showing RV focused view on 2DE (A) and 3DE (B) in the same patient.

Two-dimensional analysis of RV function

The complex nature of RV contour makes it difficult to re-construct RV shape mentally utilizing even multiple 2D imaging planes. In addition, incorporation of these scanning planes still falls short of a complete 3D geometry, therefore echocardiographers have been using surrogate parameters to describe RV function. Among these, the most frequently reported 2DE measurements for RV function are tricuspid annular plane systolic excursion (TAPSE) and RV fractional area change (FAC) by the apical 4-chamber view. TAPSE is defined as the distance traveled between end-diastole and end-systole at the lateral corner of the tricuspid annulus. TAPSE has been validated to correlate strongly with RVEF measured by radionuclide angiography, with low observer variabilities (9). In addition, it has also been validated against RVEF by biplane Simpson method and RV FAC (10,11). In a large series of 900 cases, including 150 normal subjects, a cutoff value >17 mm of TAPSE is defined as normal and the guideline recommends the use of <16 mm of TAPSE as abnormal (4,12). Of note, TAPSE is angle dependent, and measurement can be affected by sliding motion of the heart within the chest cavity. TAPSE is also load dependent, and TAPSE is increased in the presence of severe TR while in the presence of mildly reduced RV systolic function, TAPSE may appear to be within normal range. TAPSE is a one-dimensional measurement which does not always reflect global RV function. However, it is an easily obtained surrogate marker for routine practice.

FAC is the area difference between RV end-diastolic and end-systolic areas measured through ideally RV-focused apical view. The border should be traced carefully to exclude the heavy trabeculations inside the right ventricle. FAC has been validated with cardiac magnetic resonance (CMR) (13) and shown to be an independent predictor for sudden death, mortality after pulmonary embolism, heart failure, stroke, and myocardial infarction (14-16). An FAC <35% is considered abnormal by the guideline (4). FAC has the advantage of being quickly and easily obtainable parameter like TAPSE, and is one of the recommended methods alongside with TAPSE. However, since FAC is 2D measurement, its disadvantage is that it does not represent global RV function or actual RVEF.

2D RV volume quantification has been used with area-length methods and disk summation methods. The area-length method, based on the assumption of modified pyramidal or ellipsoid models for RV geometry approximation, underestimate CMR-derived RV volume and is inferior compared to 3DE derived volume (17,18). The disk summation method, primarily adopted for calculating RV “body” volume, therefore underestimates true RV volume since RV inflow and outflow parts were not included during quantification. The pooled studies of these 2DE methods derived RVEF has lower reference value of 44% with 95% confidence interval (CI) 38–50% (4). However, calculation of 2D RVEF is currently not recommended by the American Society of Echocardiography.

Doppler echocardiography analysis of RV function

The rate of pressure rise in the ventricles (dP/dt) is validated as an index of ventricular contractility or systolic function. Initially described by Gleason and Braunwald in 1962 for both left and right ventricles (19), dP/dt of the right ventricle is calculated by measuring the time required for the TR jet to increase in velocity from 1 to 2 m/s (20). Using the simplified Bernoulli formula, this is equivalent to a pressure rise from 4 to 16 mmHg and a difference of 12 mmHg. Thus, dP/dt is calculated by dividing 12 mmHg to time in seconds. An RV dP/dt <400 mmHg/s is likely abnormal. The advantage of the method is relative simple steps in the acquisition, measurement, and calculation. The disadvantage is that it is load dependent and is less accurate in patients with severe TR. Since there is lack of data in normal subjects, RV dP/dt cannot be recommended for its use in routine practice (4).

RV myocardial performance index (MPI), also known as Tei index, is a global parameter of both systolic and diastolic ventricular function (21). MPI is defined as the ratio of total isovolumic time divided by total ejection time (ET) by the formula IVRT + IVCT/ET. MPI has been shown to have good correlation with simultaneous recorded cardiac catheterization derived systolic peak +dP/dt (r=0.821, P<0.001) and diastolic peak –dP/dt (r=0.833, P<0.001) (22). MPI has shown to have predictive values in future events in patients with pulmonary hypertension, congenital heart disease, RV infarction, and hypertrophic cardiomyopathy (23-26). The upper reference limit for the RV MPI is 0.40 using the pulsed Doppler method and 0.55 using the tissue Doppler method. The advantages include feasibility and reproducibility in wide range of subjects with or without TR. The disadvantages include that it is not used in patients with irregular heart beat and those whose RA pressure is elevated.

Tricuspid annular motion can be evaluated by tissue Doppler to measure the longitudinal velocity of the tricuspid annulus. This velocity has been named the RV S' or systolic excursion velocity. To measure this parameter, RV-focused view is used with tissue Doppler region of interest placed at the lateral corner of the tricuspid annulus acquired at high frame rate. The velocity S' is read as the highest systolic velocity. A number of validation studies have been performed which showed good correlations to radionuclide angiography and CMR determined RVEF (27,28). In fact, RV S' correlated better than FAC and TAPSE when RVEF by CMR was normal to mildly abnormal (defined as <50%) but second to FAC when RVEF by CMR was severely abnormal (defined as <30%) (29). A cutoff of RV S' <11.5 cm/s correlates with RVEF <45% with a sensitivity of 90% and specificity of 85% and an RV S' <10 cm/s should raise the suspicion for abnormal RV function, particularly in younger adult patients (4).

Myocardial deformation analysis of RV function

Myocardial deformation, or strain, is defined as deformation of an object compared with its initial shape and is expressed as a percentage. RV LS is acquired using tissue Doppler imaging or speckle-tracking imaging. Since strain values by tissue Doppler imaging are angle dependent, RV LS is now measured by 2DE speckle tracking analysis. To calculate strain, high frame rates are required, thus narrow imaging sector focusing on the RV wall is desired. When analyzing RV LS, one can obtain RV free wall LS and RV global LS on the apical 4-chamber view. RV free wall LS is the strain in the RV free wall on the apical 4-chamber view. RV global LS is defined as averaged strain on the RV free wall and interventricular septum. RV free wall strain is generally higher than RV global LS. Several studies have revealed its usefulness. RV free wall LS was evaluated in patients with systemic sclerosis with normal pulmonary pressure, and has been shown to detect early deterioration of RV function (30). Cutoff value of systolic LS at the basal free wall of −25% yielded a 81% sensitivity and 82% specificity for the prediction of RVEF >50% (31). In 80 patients with World Health Organization group 1 pulmonary hypertension, average RV free wall systolic strain worse than −12.5% was associated with greater degree of disease progression within 6 months (32). A RV longitudinal peak systolic strain ≥−19% was significant associated with all-cause mortality in 150 patients with pulmonary hypertension of different etiology (33). A larger study with 575 patients with pulmonary hypertension of various etiologies, RV strain predicted survival when adjusted for pulmonary pressure, PVR, and RA pressure (34). The advantages of RV free wall LS measurements include potential means to assess myocardial contractility that is less load dependent and can be applied in a wide variety of diseases. In a study of 276 healthy volunteers, normal values of RVLS were −24.0±2.6% in men and −26.7±3.1% for women (35). In a meta-analysis of 10 studies involving 486 patients without cardiopulmonary disease, the mean RV strain was −26±4% (36). Currently, normal values of RV free wall strain were given as −29.0±4.5% in the 2015 ASE/EACVI guidelines (37).

Three-dimensional analysis of RV function

At present, the determinations of RV volumes and EF are still provided by CMR. Limitations in the availability of the facility, portability, cost, and time have however largely confined its clinical use in selected number of subjects. 3DE holds good promise to RV volumetric analysis, without the need for geometric assumption. Although 3DE systematically underestimates RV volumes, several studies have shown 3DE determined RV volumes and function correlated well with CMR with steadily improvement seen over years (Table 2) (38-46). Using RV software in the earlier days, it took longer analysis time due to tedious manual editing of RV endocardial border in every patient. With improvement of image quality of 3DE and more user friendly RV quantification software, this drawback can be eliminated in the recent publications (46). Normal range of RV volumes and RVEF have been also established (Table 3) (18,47,48). Recent publication has demonstrated the prognostic values of 3DE RVEF (49), and its clinical adoption in multicenter setting or certain cardiac diseases awaits further study. The advantages of 3DE are fast acquisition, independent of geometric assumptions, semi-automated border detection, dynamic RV cast visualization using dedicated software (Figures 2,3 and S1,S2). The disadvantage of 3DE is similar to 2DE when imaging of RV free wall is not possible due to its proximity to the sternum, a severely dilated RV cannot be imaged in its entirety by ultrasound probe.

Table 2
Table 2 Comparison of right ventricular volume between 3D echocardiography and cardiac magnetic resonance
Full table
Table 3
Table 3 Determination of normal values of right ventricular volume and ejection fraction
Full table
Figure 2 RV parameters measured by traditional 2DE (A), and by 3DE (B) in a patient with ischemic cardiomyopathy with normal RV systolic function. (A) 2D speckle tracking analysis of the right ventricle with vendor independent software (Echo Insight, Epsilon), which provides RV FAC, RV free wall strain, S' and TAPSE. In this particular case, all of these parameters are normal; (B) 3D speckle tracking analysis of the RV with vendor independent software (4D RV-Function 2, TomTec), which provides RV volumes and RVEF. RVEF is also normal. RV, right ventricular.
Figure 3 RV parameters measured by traditional 2DE (A), and by 3DE (B) in a patient with pulmonary hypertension. In contrast to Figure 2, all 2D speckle tracking derived parameters were abnormal. 3D RVEF were also depressed to 38.8%.
Figure S1 Assessment of 3D RVEF in subject with normal RV systolic function (50). RVEF, right ventricular ejection fraction. Available online:
Figure S2 Assessment of 3D RVEF in subject with abnormal RV systolic function (51). RVEF, right ventricular ejection fraction. Available online:


Understanding the asymmetrical and complex RV shape is essential to accurate acquisition, analysis, and interpretation of currently proposed RV parameters. Evaluation of RV function by 2DE have been straightforward and also been validated against gold standard CMR and with prognostic values. Assessment of RV function by 3DE includes additional dimension for quantification of true RV volume and RVEF. Clinical application of 3DE determined parameters are expected to have enhanced outcome prediction in a variety of cardiac diseases.




Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: Wu VC, Takeuchi M. Echocardiographic assessment of right ventricular systolic function. Cardiovasc Diagn Ther 2018;8(1):70-79. doi: 10.21037/cdt.2017.06.05