TY - JOUR AU - Kimura, Wataru AU - Sadek, Hesham A. PY - 2012 TI - The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors JF - Cardiovascular Diagnosis and Therapy; Vol 2, No 4 (December 18, 2012): Cardiovascular Diagnosis and Therapy Y2 - 2012 KW - N2 - Resident stem cells persist throughout the entire lifetime of an organism where they replenishing damaged cells. Numerous types of resident stem cells are housed in a low-oxygen tension (hypoxic) microenvironment, or niches, which seem to be critical for survival and maintenance of stem cells. Recently our group has identified the adult mammalian epicardium and subepicardium as a hypoxic niche for cardiac progenitor cells. Similar to hematopoietic stem cells (LT-HSCs), progenitor cells in the hypoxic epicardial niche utilize cytoplasmic glycolysis instead of mitochondrial oxidative phosphorylation, where hypoxia inducible factor 1α (Hif-1α) maintains them in glycolytic undifferentiated state. In this review we summarize the relationship between hypoxic signaling and stem cell function, and discuss potential roles of several cardiac stem/progenitor cells in cardiac homeostasis and regeneration. UR - https://cdt.amegroups.org/article/view/1286