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Clinical outcomes of PCSK9Is: a meta-analysis of randomized clinical trials

	author = {Rugheed Ghadban and Tariq Enezate and Jad Omran and Rajaa Almourani and Atul Singla and Sudarshan Balla},
	title = {Clinical outcomes of PCSK9Is: a meta-analysis of randomized  clinical trials},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {7},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {Background: Previous studies of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9Is) were not designed to detect clinical benefit and were underpowered for this outcome. However, recently published trials reported improvement in clinical outcomes. The aim of this meta-analysis to assess the impact of PCSK9Is on clinical outcomes.
Methods: Medline, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) were queried from January 2000 through March 2017. Only randomized controlled trials (RCTs) comparing clinical outcomes in patients treated with PCSK9I versus control group were included. Two independent reviewers selected the studies and extracted data in duplicate. Random-effects meta-analysis was used to pool outcomes across studies. Study endpoints included: major adverse cardiovascular events (MACE), myocardial infarction (MI), stroke, coronary revascularization, cardiovascular (CV) mortality and all-cause mortality. 
Results: A total of 62,776 patients (mean age 61 years, 73% were males) were included from six randomized clinical trials. In comparison to control group, PCSK9I use was associated with lower MACE (RR =0.81, 95% CI, 0.70–0.93, P=0.003), MI (RR =0.78, 95% CI, 0.63–0.97, P=0.03), stroke (RR =0.74, 95% CI, 0.64–0.87, P=0.0002) and coronary revascularization (RR =0.79, 95% CI, 0.73–0.86, P},
	issn = {2223-3660},	url = {}