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Shaping the future of renal denervation-the relevance of sham-controlled randomized trials and recent meta-analyses

  
@article{CDT27380,
	author = {Márcio G. Kiuchi and Jan K. Ho and Leslie Marisol Lugo Gavidia and Markus P. Schlaich},
	title = {Shaping the future of renal denervation-the relevance of sham-controlled randomized trials and recent meta-analyses},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {0},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {The overall prevalence of hypertension in adults globally is estimated to be 30–45% with even higher rates of >60% in people aged above 60 years (1). It is expected that the number of people with hypertension will further grow by 15% to 20% and reach ~1.5 billion in 2025 (2). A systolic blood pressure (BP) ≥140 mmHg contributes substantially to the mortality and disability burden (70%), mostly related to ischemic and hemorrhagic stroke (1.5 and 2 million, respectively), and ischemic heart disease (4.9 million) (3). While lifestyle modification and antihypertensive (AH) pharmacotherapy are highly effective in reducing elevated BP, many patients remain uncontrolled due to a variety of reasons including non-adherence and non-compliance, intolerance to prescribed drugs, or true treatment resistance. Some of these patients may benefit from novel interventional procedures such as catheter-based renal denervation (RDN) as a suitable alternative.},
	issn = {2223-3660},	url = {http://cdt.amegroups.com/article/view/27380}
}