%0 Journal Article %T Total Astragalus saponins attenuates CVB3-induced viral myocarditis through inhibiting expression of tumor necrosis factor α and Fas ligand %A Xiao, Yunfeng %A Liu, Tianlong %A Liu, Xiaoling %A Zheng, Lanbin %A Yu, Dongsheng %A Zhang, Yuanyan %A Qian, Xinyu %A Liu, Xiaolei %J Cardiovascular Diagnosis and Therapy %D 2019 %B 2019 %9 %! Total Astragalus saponins attenuates CVB3-induced viral myocarditis through inhibiting expression of tumor necrosis factor α and Fas ligand %K %X Background : To investigate the therapeutic effect of total Astragalus saponins (AST) against viral myocarditis in animal and cell models. Methods : Primary myocardiocytes (PMCs) were stimulated by the coxsackie B (CVB) 3 virus to prepare the cell model of viral myocarditis. Cell viability, apoptosis and the mRNA expression of C-Myc, tumor necrosis factor (TNF)-α and Fas were detected to evaluate the protective effects of AST on CVB3-induced PMC damage. Results : AST could significantly increase survival and decrease the ratio of heart weight: body weight (P Conclusions : It is demonstrated that AST was protective against CVB3-induced viral myocarditis, which may be associated with a decrease in CVB3-induced apoptosis and down-regulation of expression of C-Myc, TNF-α and Fas. %U https://cdt.amegroups.org/article/view/28599 %V 9 %N 4 %P 337-345 %@ 2223-3660