TY - JOUR AU - Xiao, Yunfeng AU - Liu, Tianlong AU - Liu, Xiaoling AU - Zheng, Lanbin AU - Yu, Dongsheng AU - Zhang, Yuanyan AU - Qian, Xinyu AU - Liu, Xiaolei PY - 2019 TI - Total Astragalus saponins attenuates CVB3-induced viral myocarditis through inhibiting expression of tumor necrosis factor α and Fas ligand JF - Cardiovascular Diagnosis and Therapy; Vol 9, No 4 (August 28, 2019): Cardiovascular Diagnosis and Therapy Y2 - 2019 KW - N2 - Background : To investigate the therapeutic effect of total Astragalus saponins (AST) against viral myocarditis in animal and cell models. Methods : Primary myocardiocytes (PMCs) were stimulated by the coxsackie B (CVB) 3 virus to prepare the cell model of viral myocarditis. Cell viability, apoptosis and the mRNA expression of C-Myc, tumor necrosis factor (TNF)-α and Fas were detected to evaluate the protective effects of AST on CVB3-induced PMC damage. Results : AST could significantly increase survival and decrease the ratio of heart weight: body weight (P Conclusions : It is demonstrated that AST was protective against CVB3-induced viral myocarditis, which may be associated with a decrease in CVB3-induced apoptosis and down-regulation of expression of C-Myc, TNF-α and Fas. UR - https://cdt.amegroups.org/article/view/28599