TY - JOUR AU - Kornhuber, Katharina T. I. AU - Seidel, Heide AU - Pujol, Claudia AU - Meierhofer, Christian AU - Röschenthaler, Franz AU - Pressler, Axel AU - Stöckl, Alexander AU - Nagdyman, Nicole AU - Neidenbach, Rhoia C. AU - Hundelshausen, Philipp von AU - Halle, Martin AU - Holdenrieder, Stefan AU - Ewert, Peter AU - Kaemmerer, Harald AU - Hauser, Michael PY - 2019 TI - Hemostatic abnormalities in adult patients with Marfan syndrome JF - Cardiovascular Diagnosis and Therapy; Vol 9, Supplement 2 (October 2019): Cardiovascular Diagnosis and Therapy [Current Management Aspects in Adult Congenital Heart Disease (ACHD): Part II] Y2 - 2019 KW - N2 - Background: Aortic root ectasia might induce hemostatic disorders in patients with Marfan syndrome (MFS) via altered blood flow and rheology. The aim of this study was to explore the hemostasis in patients with MFS compared with healthy controls. Methods: In this cross-sectional case-control study we included patients with verified MFS (n=51) and sex- and age-matched healthy controls (n=50). Main criteria were the aortic root in echocardiography and cardiac magnetic resonance imaging (MRI), and the coagulation status. Results: When compared with healthy controls, patients with MFS showed significantly increased diameters of the aortic roots (43.0±7.72 vs . 28.8±3.74 mm, P vs . 0.948±1.09, P ® tests (e.g., MP-ADP: 878.4±201.7 vs . 660.4±243.6 AU*min, P ® tests (PFA Col/ADP: 102.5±45.5 vs . 91.1±46.2 s, P vs . 28.7±2.50 s, P vs . 0.254±0.099 mg/L, P vs . 106.3%±41.5%, P vs . 118.8%±47.8%, P vs . 126.7%±28.4%, P Conclusions: In conclusion, our study reveals hemostatic deviations in patients with MFS. Further studies are necessary to understand the causal relationship and the exact pathomechanism. UR - http://cdt.amegroups.com/article/view/29689