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Accuracy of 3-dimensional and 2-dimensional quantitative coronary angiography for predicting physiological significance of coronary stenosis: a FAVOR II substudy

  
@article{CDT30157,
	author = {Daixin Ding and Junqing Yang and Jelmer Westra and Yundai Chen and Yunxiao Chang and Martin Sejr-Hansen and Su Zhang and Evald H. Christiansen and Niels R. Holm and Bo Xu and Shengxian Tu},
	title = {Accuracy of 3-dimensional and 2-dimensional quantitative coronary angiography for predicting physiological significance of coronary stenosis: a FAVOR II substudy},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {9},
	number = {5},
	year = {2019},
	keywords = {},
	abstract = {Background: Three-dimensional quantitative coronary angiography (3D-QCA) enables reconstruction of a coronary artery in 3D from two angiographic image projections. This study compared the diagnostic accuracy of 3D-QCA vs. 2-dimensional (2D) QCA in predicting physiologically significant coronary stenosis, using fractional flow reserve (FFR) as the reference standard.
Methods: All interrogated vessels in the FAVOR II China study and the FAVOR II Europe-Japan study were assessed by 2D-QCA and 3D-QCA according to standard operating procedures in core laboratories. QCA analysts were blinded to the corresponding FFR values. 
Results: A total of 645 vessels from 576 patients with 3D-QCA, 2D-QCA, and FFR were analyzed. Using the conventional cut-off value of 50% for percent diameter stenosis (DS%), 3D-QCA was more accurate in predicting FFR ≤0.80 than 2D-QCA [accuracy 74.0% (95% CI: 69.9–77.7%) vs. 64.9% (95% CI: 61.3–68.7%), difference: 9.1%, P},
	issn = {2223-3660},	url = {http://cdt.amegroups.com/article/view/30157}
}