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Kallistatin correlates with inflammation in abdominal aortic aneurysm and suppresses its formation in mice

  
@article{CDT34851,
	author = {Yuchen He and Yanshuo Han and Jia Xing and Xiaoyue Zhai and Shiyue Wang and Shijie Xin and Jian Zhang},
	title = {Kallistatin correlates with inflammation in abdominal aortic aneurysm and suppresses its formation in mice},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {10},
	number = {2},
	year = {2020},
	keywords = {},
	abstract = {Background: Kallistatin (KS), encoded by SERPINA4, was suggested to play a protective role in many cardiovascular diseases. However, its role in the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to examine the potential association of KS with AAA pathogenesis. 
Methods: We examined KS (SERPINA4) expression in human AAA by PCR, immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay (ELISA) and analyzed correlations between kallistain and clinical data. We then analyzed the effect of recombinant KS on AAA formation and the Wingless (Wnt) signaling pathway in a mouse AAA model developed by angiotensin II (AngII) infusion to apolipoprotein E-deficient (ApoE–/–) mice.
Results: In AAA tissue samples, KS was significantly increased compared with samples from the control group (P},
	issn = {2223-3660},	url = {http://cdt.amegroups.com/article/view/34851}
}