%0 Journal Article %T Lipoprotein-associated phospholipase A 2 and carotid intima-media thickness in individuals classified as low-risk according to Framingham %A Hargens, Trent A. %A Rhodes, Philip G. %A VanReenen, Jessica %A Kaminsky, Leonard A. %J Cardiovascular Diagnosis and Therapy %D 2014 %B 2014 %9 %! Lipoprotein-associated phospholipase A 2 and carotid intima-media thickness in individuals classified as low-risk according to Framingham %K %X Background: The Framingham risk score (FRS) has long been used as a global tool to estimate coronary heart disease (CHD) risk, but data has shown that subclinical CHD may exist in those classified as low risk by FRS, and as a result, there is potential for misclassification. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) and carotid intima-media thickness (CIMT) are two emerging risk markers that are predictive of future CHD events. Purpose: To examine Lp-PLA 2 and CIMT values in low risk individuals, and to explore the relationship between Lp-PLA 2 and CIMT. Methods: A total of 229 men and women (age =53±7 years) underwent body composition analysis, objective physical activity measurement, fasting blood draw to determine standard lipid values and Lp-PLA 2 mass, and CIMT measurement through ultrasound. Results: For all subjects, mean CIMT was 0.61±0.1 mm, mean Lp-PLA 2 mass was 197±45 ng/dL. A total of 19.5% and 34.6% of women and 4.6% and 73.8% of men were considered at elevated risk for CHD by CIMT (>75 th percentile for age) and Lp-PLA 2 mass (>200 ng/dL) standards, respectively. Both CIMT and Lp-PLA 2 mass were significant independent predictors of each other, whereas traditional risk markers (lipids, glucose) were not. Conclusions: Results suggest that in those classified as low risk by FRS, evidence of increased CHD risk may exist through the use of newer risk markers like CIMT and Lp-PLA 2 . These emerging markers may aid in the earlier detection and intervention of subclinical CHD. %U https://cdt.amegroups.org/article/view/5330 %V 4 %N 6 %P 487-494 %@ 2223-3660