@article{CDT11492,
author = {Alberto Cresti and Mario Chiavarelli and Marco Scalese and Cesira Nencioni and Silvia Valentini and Francesco Guerrini and Incoronata D’Aiello and Andrea Picchi and Francesco De Sensi and Gilbert Habib},
title = {Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {7},
number = {1},
year = {2016},
keywords = {},
abstract = {Background: The population at risk, the clinical and microbiological features of infective endocarditis (IE) have changed. Aim of our study was to evaluate the contemporary epidemiological trends, over a
17-year period in a definite region of Tuscany, Italy, to analyze the clinical outcomes and associated prognostic factors.
Methods: From 1 January 1998 to 31 December 2014, all patients with a definite diagnosis of IE were prospectively entered in a data-base. The Health-Care system data-base was interrogated to capture patients who could have been missed. The final dataset derived by the merging of the two data-bases.
Results: Incidence rate of IE was 4.6/100,000/y with a significant linear incidence increase. In hospitalized patients the incidence was 1.27/1,000 admissions. Over age 65 incidence rate was 11.7/100,000/y. Male/female ratio was 1.54:1. A temporal trend towards an increase in the mean population age was found (P=0.033). There was an increase in the incidence of Health-care associated IE, P=0.016. The most common microorganisms were staphylococcus aureus (25%) and coagulase-negative staphylococci (22%). In-hospital mortality was 24%. A trend towards an increase in mortality rate was found (P=0.055). Independent predictors of mortality were older age, S. aureus infection, heart failure, septic shock and persistent bacteremia.
Conclusions: Our study confirms an increasing mortality trend in IE, although with a borderline significance. Elderly forms are associated with poor prognosis and higher than 1-year mortality rate even in the multivariate analysis. Ageing population, increase in healthcare-associated and staphylococcal infections, may explain the rise of IE incidence and of the mortality trend.},
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/11492}
}