TY - JOUR AU - Cresti, Alberto AU - Chiavarelli, Mario AU - Scalese, Marco AU - Nencioni, Cesira AU - Valentini, Silvia AU - Guerrini, Francesco AU - D’Aiello, Incoronata AU - Picchi, Andrea AU - Sensi, Francesco De AU - Habib, Gilbert PY - 2016 TI - Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study JF - Cardiovascular Diagnosis and Therapy; Vol 7, No 1 (February 01, 2017): Cardiovascular Diagnosis and Therapy Y2 - 2016 KW - N2 - Background: The population at risk, the clinical and microbiological features of infective endocarditis (IE) have changed. Aim of our study was to evaluate the contemporary epidemiological trends, over a 17-year period in a definite region of Tuscany, Italy, to analyze the clinical outcomes and associated prognostic factors. Methods: From 1 January 1998 to 31 December 2014, all patients with a definite diagnosis of IE were prospectively entered in a data-base. The Health-Care system data-base was interrogated to capture patients who could have been missed. The final dataset derived by the merging of the two data-bases. Results: Incidence rate of IE was 4.6/100,000/y with a significant linear incidence increase. In hospitalized patients the incidence was 1.27/1,000 admissions. Over age 65 incidence rate was 11.7/100,000/y. Male/female ratio was 1.54:1. A temporal trend towards an increase in the mean population age was found (P=0.033). There was an increase in the incidence of Health-care associated IE, P=0.016. The most common microorganisms were staphylococcus aureus (25%) and coagulase-negative staphylococci (22%). In-hospital mortality was 24%. A trend towards an increase in mortality rate was found (P=0.055). Independent predictors of mortality were older age, S. aureus infection, heart failure, septic shock and persistent bacteremia. Conclusions: Our study confirms an increasing mortality trend in IE, although with a borderline significance. Elderly forms are associated with poor prognosis and higher than 1-year mortality rate even in the multivariate analysis. Ageing population, increase in healthcare-associated and staphylococcal infections, may explain the rise of IE incidence and of the mortality trend. UR - https://cdt.amegroups.org/article/view/11492